Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
-
Sodium Channel
(627)
View all products
-
Nav1.1
(11)
View all products
-
Nav1.2
(16)
View all products
-
Nav1.3
(14)
View all products
-
Nav1.4
(14)
View all products
-
Nav1.5
(21)
View all products
-
Nav1.6
(12)
View all products
-
Nav1.7
(61)
View all products
-
Nav1.8
(41)
View all products
-
Nav1.9
(2)
View all products
All Product Categories
-
Sodium Channel Inhibitors
(619)
View all products
-
Sodium Channel Agonists
(10)
View all products
-
Sodium Channel Antagonists
(30)
View all products
-
Sodium Channel Activators
(35)
View all products
-
Sodium Channel Modulators
(28)
View all products
-
Sodium Channel Controls
(5)
View all products
-
Sodium Channel Ligands
(3)
View all products
-
Sodium Channel Related Products (800)
Related Products (800)
-
Antibodies (9)
-
Related Compound Screening Libraries (1)
-
Sodium Channel Isoform Comparison
-
Eslicarbazepine Acetate-d3
0 ImagesCat. No.: HY-W744263CAS No.: 2512192-54-8Eslicarbazepine Acetate-d3 is the deuterium labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
-
ProTx-III
0 ImagesCat. No.: HY-P5153CAS No.: 1808297-63-3Synonyms: μ-TRTX-Tp1aProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia.
-
PA1
0 ImagesCat. No.: HY-125667CAS No.: 1620951-72-5Synonyms: Photoamiloride-1PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively.
-
Eleclazine
0 ImagesSynonyms: GS-6615Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias.
-
JNJ-26990990
0 ImagesCat. No.: HY-12155CAS No.: 877316-38-6JNJ-26990990 is a broad-spectrum antiepileptic agent with oral activity. JNJ-26990990 can inhibit voltage-gated Na+ channels and N-type Ca2+ channels, but has a very weak inhibitory effect on human carbonic anhydrase-II (IC50 = 110 μM).
-
Dichlorobenzamil
0 ImagesDichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits 45Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC50 = 18 μM). Dichlorobenzamil can also block K+ channels and voltage-sensitive Ca2+ channels.
-
Denzimol hydrochloride
0 ImagesCat. No.: HY-105059ACAS No.: 77234-90-3Denzimol hydrochloride is an orally active anticonvulsant agent. Denzimol hydrochloride inhibits cytochrome P450, and interacts with benzodiazepine receptors. Denzimol hydrochloride selectively antagonizes tonic components of Metrazol-induced seizures in rats and mice. Denzimol hydrochloride can be used for the research of epilepsy and convulsions.
-
Nav1.7-IN-8
0 ImagesCat. No.: HY-141547CAS No.: 1432913-44-4Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5. Nav1.7-IN-8 inhibits CYP2C9 and CYP3A4 with an IC50 of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 displays significant analgesic effects in rodent models of acute and inflammatory pain.
-
PF-05150122
0 ImagesCat. No.: HY-128794CAS No.: 1235406-00-4PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain signaling. PF-05150122 exhibited favorable biopharmacokinetic parameters in microdose studies, providing a basis for exploring its application in acute or chronic pain inhibition. The pharmacokinetic model of PF-05150122 predicted that at the corresponding oral dose, it could effectively reduce the 50% inhibitory concentration (IC50) of Nav1.7, demonstrating its inhibitory potential.
-
KT 2-230
0 ImagesCat. No.: HY-106731CAS No.: 134296-41-6KT 2-230 is a sodium channel and calcium channel blocker with anti-inflammation effects.
-
NaPi2b-IN-1
0 ImagesCat. No.: HY-142957CAS No.: 1453116-06-7NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia.
-
ASIC-IN-1
0 ImagesCat. No.: HY-147391CAS No.: 308088-10-0ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity.
-
Flunarizine-d8 dihydrochloride
0 ImagesCat. No.: HY-B0358ASFlunarizine-d8 dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
-
AZD-3161
0 ImagesCat. No.: HY-117714CAS No.: 1369501-46-1AZD-3161 is a potent and selective blocker of NaV1.7 channel, with a pIC50 of 7.1. AZD-3161 can be used for the research of neuropathic and inflammatory pain.
-
BTS 72664
0 ImagesCat. No.: HY-182548CAS No.: 165383-52-8BTS 72664 is a broad-spectrum, non-sedating, orally effective anticonvulsant. Its anticonvulsant effect mainly arises from enhancing GABAA receptor (GABAA receptor)-mediated chloride channel currents, while it exerts weak blocking effects on Na+ channels (Ki = 350 μM) and NMDA receptors (NMDA receptor) (IC50 = 43 μM). BTS 72664 prevents the elevation of extracellular glutamate, glycine and serine concentrations in neurons, reduces cerebral infarct size, promotes functional recovery, prevents multiple types of epileptic seizures, and has low sedative potential. BTS 72664 can be used for the research of epilepsy, stroke and migraine.
-
20(S)-Ginsenoside Rg3 (Standard)
0 ImagesSynonyms: 20(S)-Propanaxadiol(Standard); S-ginsenoside Rg3 (Standard)20(S)-Ginsenoside Rg3 (Standard) is the analytical standard of 20(S)-Ginsenoside Rg3. This product is intended for research and analytical applications. 20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
-
Lorajmine
0 ImagesCat. No.: HY-105929CAS No.: 47562-08-3Synonyms: 17-Monochloroacetylajmaline
-
Rufinamide (Standard)
0 ImagesSynonyms: CGP 33101 (Standard); E 2080 (Standard); RUF 331 (Standard)Rufinamide (Standard) is the analytical standard of Rufinamide (HY-A0042). This product is intended for research and analytical applications. Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome.
-
Idrevloride
0 ImagesCat. No.: HY-132818CAS No.: 1416973-63-1Synonyms: P-1037Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders.
